In a case of unilateral leg redness and edema, which sign may indicate deep vein thrombosis?

In cases of unilateral leg redness and edema, Homan's sign is traditionally considered an indicator of deep vein thrombosis (DVT). This sign is evaluated by having the patient extend their knee and then dorsiflexing the foot. If this maneuver provokes pain in the calf, it is suggestive of DVT due to the irritation of the thrombosed vein.

While Homan's sign has been used historically, it is important to note that it is not a definitive diagnostic test for DVT—its sensitivity and specificity are low. However, it remains a commonly referenced sign in clinical practice, particularly in scenarios where immediate access to imaging may be limited.

The other signs mentioned do not relate to deep vein thrombosis. The Trendelenburg sign assesses venous competence and is used primarily for evaluating venous insufficiency, while the Cloverleaf sign is not a recognized clinical sign. The Babinski sign is used to assess neurological function, particularly regarding upper motor neuron lesions, and has no bearing on intrinsic venous issues in the leg. Thus, Homan's sign stands out in this context as the most relevant clinical sign for indicating the possibility of DVT.