What is the first-line treatment for erythema multiforme to prevent further outbreaks?

Acyclovir is the first-line treatment for erythema multiforme, particularly when there is a suspected viral trigger, such as herpes simplex virus. Erythema multiforme often presents with characteristic target lesions and can be associated with recurrent outbreaks, especially in individuals who have a history of herpes simplex virus infections. Acyclovir helps to reduce the viral load and can prevent further outbreaks by managing the underlying viral infection.

The role of antiviral treatment in this condition targets the precipitating factor, which is crucial in preventing recurrence. Given that the clinical manifestations of erythema multiforme might be triggered by recurrent viral infections, utilizing acyclovir aims not only to address the existing lesions but also to minimize the chances of future occurrences linked to viral reactivation.