Which extra-articular manifestation is most commonly associated with ankylosing spondylitis?

The extra-articular manifestation most commonly associated with ankylosing spondylitis is uveitis. Uveitis is an inflammation of the uveal tract of the eye and is known to occur in a significant number of patients with ankylosing spondylitis, especially given its association with the HLA-B27 antigen. Patients suffering from ankylosing spondylitis may experience episodes of uveitis, which can lead to symptoms such as eye pain, redness, sensitivity to light, and visual disturbances.

While inflammatory bowel disease and other manifestations like psoriasis and cardiac involvement can occur in patients with ankylosing spondylitis or share a common pathophysiological link, uveitis remains the most clinically significant and prevalent association with this condition. Hence, recognizing uveitis as a common extra-articular complication of ankylosing spondylitis is crucial for prompt diagnosis and management to prevent potential visual impairment.