Which medication is recommended for a 36-year-old man with combat-related irritability, nightmares, and flashbacks?

In this scenario, the recommended medication for the 36-year-old man experiencing combat-related irritability, nightmares, and flashbacks aligns with the therapeutic use of sertraline, which is a selective serotonin reuptake inhibitor (SSRI). SSRIs are commonly prescribed as first-line treatments for post-traumatic stress disorder (PTSD), and sertraline, in particular, has been shown to be effective in alleviating the symptoms described, including irritability, nightmares, and flashbacks. Its efficacy in managing PTSD symptoms is supported by clinical studies and guidelines, making it a suitable choice for this patient's presentation.

Fluoxetine, paroxetine, and other SSRIs may also be considered in treating PTSD; however, sertraline is frequently preferred due to its favorable side effects profile and evidence supporting its use in this specific condition. It helps increase serotonin levels in the brain, which can improve mood, reduce anxiety, and help regulate sleep patterns.

This understanding of sertraline's role in treating symptoms stemming from trauma helps clarify why it's the most appropriate option in this case.